Maternal thyroxine and 3,5,3'-tri-iodothyronine kinetics in near-term pregnant rats at two different levels of hypothyroidism.
نویسندگان
چکیده
Thyroid hormones are extremely important for development of the fetal central nervous system. Thyroidectomy results in severe hypothyroidism. In this study two levels of maternal hypothyroidism were reached by administration of different amounts of thyroxine (T4) and 3,5,3'-tri-iodothyronine (T3) to thyroidectomized pregnant rats. We examined the production, distribution and transport of T4 and T3 by performing a kinetic experiment (three-compartment analysis) with intact and thyroidectomized near-term pregnant rats which received either very low (Tx + lowTH) or normal (Tx + TH) doses of T4 and T3. Despite administration of normal doses of thyroid hormones, plasma TSH was still elevated in the Tx + TH rats, meaning that these rats were still mildly hypothyroid. The Tx + lowTH rats were markedly hypothyroid, the plasma T4 and T3 levels being very low. In the mildly hypothyroid rats the transport of T4 from plasma to the fast pool and vice versa was decreased compared with intact near-term pregnant rats. This could imply that much less T4 is transported to the feto-placental compartment. Liver type I deiodinase was decreased, resulting in lowered plasma T3 values. In the markedly hypothyroid rats all pools and rates of transport of T4 and T3 were greatly decreased. In conclusion, even mild hypothyroidism, despite normal plasma T4 values, results in significant changes, especially in maternal T4 transport. We suggest that even mild maternal hypothyroidism will have a negative effect on the availability of maternal T4 for fetuses.
منابع مشابه
Urinary iodine excretion and maternal thyroid function. During pregnancy and postpartum.
OBJECTIVE To evaluate urinary iodine excretion during the course of pregnancy and postpartum in relation to maternal and neonatal thyroid function parameters in Saudi women living in Jeddah, Kingdom of Saudi Arabia. METHODS A prospective longitudinal study was conducted on Saudi normal pregnant women during the course of pregnancy (N=80), at term and 6-10 weeks postpartum (N=65), during the p...
متن کاملEffects of marginal iodine deficiency on thyroid hormone production, distribution and transport in nonpregnant and near-term pregnant rats.
During pregnancy maternal thyroid hormones are of great importance for normal development of the central nervous system of the fetus. Iodine deficiency of the mother carl result in an impaired development of the fetal brain. In large areas of the world iodine intake is moderately low. To study the effects of marginal iodine deficiency (MID) on the production, distribution, and transport of thyr...
متن کاملCongenital hypothyroidism, as studied in rats. Crucial role of maternal thyroxine but not of 3,5,3'-triiodothyronine in the protection of the fetal brain.
To study the protective effects of maternal thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in congenital hypothyroidism, we gave pregnant rats methimazole (MMI), an antithyroid drug that crosses the placenta, and infused them with three different doses of T4 or T3. The concentrations of both T4 and T3 were determined in maternal and fetal plasma and tissues (obtained near term) by specific RIA...
متن کاملMaternal thyroid function at 11-13 weeks of gestation in women with hypothyroidism treated by thyroxine.
OBJECTIVE The aim of this study in pregnant women with hypothyroidism treated by levothyroxine is to examine the interrelations between thyroid-stimulating hormone (TSH), free thyroxine (FT(4)) and free tri-iodothyronine (FT(3)), and examine whether in such patients the treatment is adequate. METHODS This was a retrospective cross-sectional study. Maternal serum concentrations of FT(3), FT(4)...
متن کاملThe effects of amiodarone on thyroid function.
The effects of amiodarone on thyroid function tests in 100 patients treated for 6 weeks to 8 years are reported. One patient became thyrotoxic and 10 developed latent or overt hypothyroidism. Twenty-five patients remained clinically euthyroid throughout, but had free thyroxine indices above the normal range. In these patients with apparently anomalous results, total tri-iodothyronine was normal...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- European journal of endocrinology
دوره 138 1 شماره
صفحات -
تاریخ انتشار 1998